@dupzor - well the love and hate is only 5 damage points better than the regular spiked knuckles but, i still think it's worth getting... also, if your an unarmed kind of player, keep your eye out for the ballistic fist... it packs a shotgun-like punch that usually knocks enemies back, plus it can deal about 100 in damage if your unarmed skill is stellar... that is actually my favorite weapon in all of new vegas ...
there's also pushy, a unique power fist located in a cave on the march up to jacobstown... be careful though, one of those caves up there is by far one of the toughest to get through... i call it cazador hell...
there's also a zap glove which works like a pulse grenade and sends an EMP shock when used... perfect for robots and power armor...
for energy weapons, if you haven't taken the wild wasteland perk, there's a unique gauss rifle way up north in an unmarked location... it's called the YCS/186 and it is a very deadly sniper rifle, usually dealing around 140 in damage if your good in that skill... it's NE of brooks tumbleweed ranch, north of north vegas...
keep collecting the sunset sarsaparilla star bottle caps because collecting 50 of them yields an awesome unique laser pistol that deals over 100 in damage too... i won't spoil the location of that one though but, by the time you find 50 star caps, i am sure you've found the location as well...
for melee the unique fire axe in camp searchlight is another great weapon to have (science skill of 50 required)... as well as the infamous chainsaw... you'll run across the unique super sledgehammer if you do the quest in jacobstown, which is probably the most powerful melee weapon outside the chainsaw... the chainsaw is wielded by some legion members once you get to around level 16 and above... and found rarely in stores after level 16 too... so is the always cool weapon, the shishkebab... hell, even the simple lead pipe is a useful melee weapon...