We had these "random" encounters with strangers in GTA IV and even RDR with people giving us stupid little side missions to complete, so will this continue in GTA V? Many of them had an actual life that progressed (or deteriorated) as the game went on which made it interesting to do them and see where their lives went.
OPx just gave me a good idea for one: We find an up-and-coming actress who ends up doing porn. (fits perfect in Vinewood) We could end up rescuing her from that lifestyle later or she ends up making it big in porn.
So what other kinds of these side missions would you like to see or think will fit in GTA V?